Sleep. In real life, I only have to find a kind place to lay down. But in game, there is always more difficult to let my character have a nice snap.
Daydream. Few game cares about how their characters daydreaming.

Looking around without having to move your whole body and driving with a manual shift.

Staying on the right side of the road is harder in games than in real life. #RazerxGOG

Jump up onto a 1ft-high rock

or

Have conversation threads that make sense!

(1)
its harder to avoid CTD's in games then in real life (looking at you bethesda...)

(2)
installing cybernethics

(3)
feeling immersed

(4)
controlling your curiosity in tricky, dangerous or terrifying situation.

(5)
getting the right materials to fix or craft something.

most games: find this item somewhere in the map, there is only one left of it

Real life: order on internet

person: oh.. it was just a single micro chip...

Welp as much as i love games. there are lots of things that are definitely harder to do in games than in real life. I could enjoy games all I want, buy games and everything, but I could never feel it physically. In real life you could do everything you want but in games you're bound to the rules made by the creator.

1) Jumping over a tiny fence, like in The Witcher 3.
2) Picking up a specific object on a crowded table.
3) Climbing down ladders.

My top 4 thing that are harder in videogames:
4) Video game combos:
2 f 1 , MAX , 2 f 1 , d d/b b 2 , dash , f 1+2 , d 4 f 3 , d 4 d d/b b 1 3 , d d/f f d d/f f 2 , f f f 2 , d 2+4
while real life combos:
left puch - rigth puch... kick maybe?

3) Video games special moves:
pretzel imput.... please no

Real life special moves:
pull triger ( naughty :( )

2) Video game side missions:
Protect this random npc while he tries to catch arrows with his face.

Real life side missions:
Play video games (a.k.a. procrastinate)

1) Videogame name choosing:
Sir DarkLord Rodney the first
Taken, what about: Sir DarkLord Rodney the first 99
"something inappropriate"
Welcome "something inappropriate"...

Real life name choosing:
Paulie if boy, Marie if girl.

In my experience is harder doing a surgery in videogames than in real life, I know it by comparing a heart transplant in surgeon simulator 2 to a real patient the last week.

Thanks, GOG and Razer, for the competition! Different types of games may have limitations that are hard to overcome or the change can be awkward, pointless, and/or so forth if the variation is implemented.

1. In the 2D old school fighting games with the health bars and a versus combat mode, the player has trouble with escaping from the enemy because the fighter can't go out of the camera's view due to the obstacle. There is no magically invisible wall around me.

2. Within specific first person shooter games, the individual lacks the ability to move backwards (to not enter the opponent's trap) and can't turn the head to the left or right while firing in a different direction to realize if there are more foes around him/her that may attack from the side and/or from behind. Also, the in-game victim doesn't blink because that could be fatal and/or annoying if the player gets shot while the eyelids are closed.

3. Inside certain top down games, the being is unable to look at the sky above the head since the player is not going to shoot any projectiles up at the sky which wastes time and/or possibly the ammunition. If I possess a firearm, I can aim at the sky but in a top down game the aim might be useless.

4. In a turn-based game, the player controlled unit does not automatically and impulsively perform an action as swiftly as possible against an enemy because it waits for input. In real life, the person could likely attempt to respond fast if the being knows about the danger and should not wait for the opponent to harm him and/or her.

5. Within specific open world games, it is hard for the protagonist to daydream about how beautiful the environment is. Certain humans do ponder about the surroundings in real life.

6. Inside a survival game, the player doesn't get bored from repeating the same tasks. In addition, there seems to be no stress (even after working for many hours) which can make the in-game individual react more like a robot than a person.

7. In many massively multiplayer online role-playing games, the non-player characters use the same responses for each player as if the beings are equal. In actual life, we may judge others by appearance, attitudes, et cetera.

8. Within a retro 2D platforming game, the protagonist's field of view can't go beyond the side of the graphical user interface if he or she doesn't move. The normal people of real life have the ability to eventually notice something that is far and in front.

9. While playing games with an urban setting and multiple cars, the real person could focus too much on the vehicle itself which can make it more difficult to avoid crashing into a thing. A real experienced good driver looks through the windshield (to concentrate on the environment) and should be able to control the acceleration more precisely than a button that could have an issue with keeping the in-game vehicle's speed consistent. The button might be pressed or unpressed but a car pedal can be kept at a certain elevation. Plus, the in-game driver never gets motion sickness no matter how long the driving lasts and/or how many times the player has moved a vehicle.

10. Inside a modernized city game, a police officer usually tries to fire the bullet at the victim without telling it to give up. In many cases, the law enforcement officers of reality arrest the suspect instead of trying to commit careless homicide first.

11. In a visual novel game, the being can find it hard to not speak and ignore the others since the story might be ruined if the main character is constantly quiet. There are silent people in real life that don't prefer those that talk too much.

12. Within certain class-based RPG games, it is possible to play as a priest that murders too many enemies and it is difficult for the cleric to show any regret. The actual priests of reality may be against violence by being peaceful.

13. Inside a game with multiple puzzles, there might be a challenging task that causes the player to get stuck and the game is incomplete during that time.

14. In plenty of point and click games that have an inventory system, the player typically starts out with no money or not enough money and has to obtain the missing item to progress. In real life, certain humans buy the object that is wanted which should be at least morally safer than stealing a thing from the area around the individual.

15. Within an endless running mobile game, it could be hard to slow down and the game would likely be easier if that is possible.

16. While playing a town or city building simulator, it is commonly not possible for the real person to look at the entire inside of each building. In reality, the structure's internals are checked to make sure those are built properly.

17. It is normally difficult to beat the virtually never ending games with a game over mechanic.

18. Inside an "escape" game, being free is usually complicated to achieve. In actual life, a lot of people bring a smartphone with a subscriber identity module card and can call if the assistance is needed. Also, the smartphone has a global positioning system which may reveal the location if the human is lost.

The hardest things to do in games that are harder than in real life:

Have you thought about climbing trees or walls? Maybe in real life we can't climb a 300 hundred ft church and live for telling our friends about that adventure. But when we are kids, we climb the walls that separate the house from the neighbors everytime. We also climb trees and we could spend 3 hours up there until our parents have gotten angry becuase we are not in time for lunch or dinner. But in games... it has to be an special tree, an special building. And you can only climb it from an specific spot. And in a lot of games. You can't even jump a little taller so you could see what is happening at the other side of the wall. It is impossible to know if the monster is waiting for us becuase the protagonist can't even jump and get curious.

At the other hand, why is extremely complicated to solve puzzles? For instace you need a driller for opening a locker door. Inside the locker there is a clue that leads into a whole new area. But the door has 5 different lockes and keys and it is impossible to open until you play the game for two more hours.

Finally, but not least. Escaping from monsters... Maybe it is complicated to be chased by a monster on real life. But... when you are playing a game. It seems that your character is weak and silly. It gets tired when running. It can't jump above obstacles. It can't hide in some dark corners because the monster is 500 times more intelligent than the character. Is annoying.

There could be a lot of more things harder in games than in normal life.

Having an open conversation.

Even in games that are dedicated to having conversations with NPCs, you only have a few options for each line of dialog of your character.

Until NPCs AI take a leap foward, this is a limitations that acompanies most, if not all, games.

Well, for me the hardest thing is probably playing by the rules and not causing havoc. Videogames are probably the most interactive form of media where anything is possible and most of the time there are (almost) no consequences and you can let your imagination run wild. Games like Grand Theft Auto, Saints Row etc. let you do some real damage to the city and its unfortunate residents with zero consequences and RPGs like The Elder Scrolls or Fallout (for example) let you play any kind of character you want so if you want to roleplay as a total douchebag you can do that.

Other than that climbing ladders (and any kind of obstacle in general) and looting/picking up items. Some games have super sensitive movement so if you make even one tiny step you can fall to your death or get stuck in a corner. In order to pick up an item you have to be in a specific spot and sometimes other objects may get in the way and you can't pick it up. Thankfully we don't have to deal with these inconveniences in real life.

What's harder to do in games than in real life? To feel the relentless passing of time, that makes our lives so short and every moment so unique and precious (in my humble opinion).

In games it's harder to get old. :) In the real world time flows constantly and we get older with every day. Now try to launch a game. With the exception of a few titles, you can leave the game working for years of real time and the main character won't get older. What more, he often doesn't get older even if we apply the game time flow rules, which are a multiplication of real time flow speed! Time simply doesn't leave a scratch on player characters, NPCs and mobs. They're forever young! :) I envy...