BlackSun: Same here, Win7.
CTD after changing game to run on secomdary display at super wide resolution, then installed new nVidia drivers. Worked. Tried again, but CTD after creation, right after wiping the mirror. Custom character, gone.
Did that again, and CTD even before I get to the mirror.
I've been playing for a while now, and it runs much better with fewer issues in the city. I think it's the starts that got it the worst.
As for what I did, I simply... don't know. I was stubborn and tried it like... 4 or 5 times? Creating character, and quicksaving (F5) as soon as I could ingame to get past the mirror scene, since that one seems to be one of the biggest issues. Later on, in the city apartment, the bathroom mirror does the same, except I never got that one to work ever, whereas the Nomad start mechanic's window worked well enough - 1st crash was after wiping the mirror. 2nd crash was while wiping the mirror. 3rd crash was immediately on seeing the mirror. 4th one crashed in the loading screen basically. May have mixed up the order of the last two, but something among those lines anyways. Then, it just... kind of worked.
Well, at that point, I was already spamming F5 on loading in, and the game told me the action was blocked. Maybe that's what "distracted" the game long enough for me to actually get past the mirror scene and get a quicksave in? Ran fine afterwards though, even if it did CTD here and there still.