I redownloaded it last night on another pc so it could have been 2.5.1 ,
on this pc I have a gtx970 card and overseer wouldn't play at all past the screensaver warning.
after dgvoodoo works great but I was having mouse locking up problems until I restarted the pc.
I think I had to reinstall the ffdshow file also. this is on windows 10 x 64

Still having no overt problems with the 16.5.3 AMD Crimsons and the game (latest drivers) and the same GPU, an R9 380 4GB...I feel fortunate about that, reading this thread. ...