I have the exact same problem, i just cant play the game like this. The mouse jumps sometimes far to the left if you try to make a circle it works one then next one is more like a egg, its horrible.
if i change to Window Mode then it works perfect, but no matter what resolution I select on the GOG configuration the window is always the same small size. I already tried Autolock=false.
In Fullscreen I always have the same Mouse acceleration problem, is there any way to get the Window Size bigger in Window mode? That seems to be the only solution.

my Mouse: Logitecg G402

*EDIT* I managed to change the Window Size now by changing from Surface to Overlay, but in Fullscreen its stills ame Problem.

*EDIT2* THIS ACTUALLY works perfect now!
1. Tool to run Dosbox with Borderless Fullscreen
2. a 100% black picture, opened in Fullscreen in background (so no desktop icons are visible)
3. TaskBar Eleminator so the taskBar disappears 100% (not just 99% like usual)

this makes the game run without any mouseproblems, 100 %fullscreen (4:3), nothing else to see on screen

the only downsight, but its really a small matter, Moo2 is completely on the left side of the screen its not centered now, so instead of on the left/right black bars its now compeltely to the left with a bigger black bar on the right. Still 100% enjoyable!

*EDIT3* with the Freeware WinSplit Revolution I even got the window now in the center of the screen with a Hotkey, now it looks 100% like real Fullscreen without the Fullscreen bugs :)

Does anyone know if its possible to get with Dosbox the window to widescreen? No matter what resolution i select, if Aspect Ratio is selected or not, I always get 4:3 resolution in windowmode.