I have two external bluray drives, headset, and a USB mouse connected to my rig, and the game runs perfectly fine.
First trying running it in its native resolution.
Typically it's a driver issue. If your drivers are up to date, then make sure you have DirectX 11, since this game's exectuable was probably configured with that in mind since its on GOG now.
Sometimes you also need to update your sound drivers. Some of us still use a separate sound card, which means you need to check that those drivers, or your motherboard's sound drivers, are up to date. Even though you hear the whip or see the intro animation, there are issues with how the data is processed and converted to sound.