I've never really played guilty gear before and I set the difficulty to beginner as well.
The whole arcade mode / story mode is quite easy, but I never manage to beat I-NO!
She's like an uber-beast!!

Any hints? :3

She is tricky. The orb blasts( or whatever you call them. )are hard to work around You can Dodge most of it. It will show two paths then she will act on the second. jump over her when she does the full screen pattern (don't hit her until she's done) and try to walk under the wave patterns. If you get hit you can use the bursts.

While I can't give you any character-specific strategies, I can give you general tips for this boss.

You'll generally want to block and poke I-No with attacks. Blocking (high and low) is very important here, as the AI will relentlessly combo you if it catches you off guard, likely into one of her two Overdrives if she has the Tension available. Do not jump if she has more than 50% tension, unless you want to eat a Genkai Fortissimo (that radial soundwave super). It hurts, but not as much as what's coming up.

After getting some hits in, the background will go completely dark (warning sign), and she'll begin to perform a rather nasty boss-exclusive attack called "Megalomania" that has three variations which need to be avoided differently. Here's a helpful comic explaining how to defend yourself against each of them: http://www.leblackdragon.com/hz/archive_page.php?comicID=84

Another option is that you can use is Faultless Defense by holding Back + any 2 attacks (except Dust) to lower the damage you take from Megalomania. You'll need at least 20% in your Tension Gauge to use this, and Tension is drained while it is active. Also, that Tension would have better use, like for your own Overdrives.

Hope this helps.

The only way I've been able to beat her so far on my 2 playthroughs with Jam and Baiken is to just try and survive until I have my tension meter at 100% and then land the Instant Super Move Kill thing on her. I tried beating her without the super move and I just couldn't do it.

I don't like that they made her hits so uber strong compared to what it's normally suppose to be. She can drain like 50% or more health with a few hits. I get that a boss has to be hard, but this just seems cheap.

Boss I-No is as hard in this as it is in the PS2 versions. Tricky but doable.

Welcome to the Guilty Gear franchise. I-No is known for being unreasonably hard. I've never beaten her.

Gold Sol and Gold Justice are like 10 times as hard as Boss I-No. I have never, ever beaten them.

On the other hand it's Mission Mode, and there are OTHER limits besides the characters being the golden variants.

Well, I thought that the boss of Guilty Gear on the PS1 was bad. Apparently, that was nothing.

After three solid hours of trying, this game has reduced me to angry, hateful tears. I don't think I'll be playing this game much, this stupid boss isn't even fun. At least when Arc System Works released BlazBlue they fixed this unbearable design flaw that utterly ruins the game.

She really bothered me years ago, but picking it up again recently I've found her less difficult. Being aggressive and knowing how to defend against those silly danger super whatchamacallits goes a long way. Get ready to walk under the wave, and jump over her full screen attack, and if you get hit then burst, or use whatever that special block thing is called when you hold back and kick and punch (the green shield thing.) That will help minimize the damage.

Tried fighting I-No without a pad.

Goddamn, not being able to pull off the supers consistently really makes her much much harder.

Using Ky, corner her with those bolts he has (moving the pad 1/4th circle and a sword attack button) If your precise in your movements you can constantly fire those off and beat her with ease.

You should perhaps try a different character. I went with Dizzy, and had a pretty hard time with two fights preceding I-No, and I quit on I-No after trying about 20 times. Then I had an idea :) I changed round time to 30 seconds, staggered my way back to I-No and then just avoided Megalomania (read the comic :)), and put in a few counter attacks - still took me a dozen tries because she'd corner me and then do that nasty super, but in the end I emerged victorious. Cheap, perhaps, but at least it's not cheating.

Today, however, I tried out Slayer and Venom. Results? Slayer - lost once to Potemkin and once to I-No. Venom - was three fights till I-No, no defeats, but I had to stop playing abruptly. Perhaps I'm just getting better, though :) (Note: Normal difficulty)

This is using the keyboard, by the way. I have a gamepad plugged in, but I suck with it and use it for trying out moves that require multiple keypresses / practising to suck less with it.

Some potentially helpful notes for other keyboard users:

1) If you've taken a look at the special moves list or a FAQ dealing with them, you've noticed that a lot of them require the quarter circle forward/backward (D, DF, F or D, DB, B) movement. However, I've found that lots of moves actually work if you do just DF / DB. Same goes for half circle f/b - instead of the whole combination, some work fine with just BDF (FDB), although this is much rarer. I suppose this is due to ghosting? Doesn't matter, it makes it easier (I don't mind the QCF/B, but HCF/B is difficult to pull off reliably).

2) Since inputing more than two or three keys at once usually doesn't work (some keyboards are better than others, ie anti-ghosting), you're cut off from some features - namely, Roman Cancel (and Fake Roman Cancel) and instant kill. Or so it seemed. If you look at the key config, you'll see various combinations under Memory - so you can assign two of those - I use one for RC and one for instant kill.

(I realize some or all of this might be obvious to everyone else, but perhaps someone as clueless as I was will find it useful. Excuse the rambling, it's late and I'm still feeling sick.)

Eh, I was using Sol, to compare just how hard it would be to do so with both pad and keyboard. Can't pull off supers as consistently with the pad, and can't do bursts (because I forgot what the combination for those is, haha, I use L1 normally). Strangely, I can pull off a simplish combo better with the keyboard, but otherwise I much prefer the pad.

All in all, still less horrible than trying to get Dizzy's last story path. Goddamn THAT is infuriatng.

I finally beat her by setting rounds to 1, and won much faster than I expected. A big psychological boost to know I only had to beat her once. Having to beat her twice practically in a row was very intimidating.

Welcome to the world of fighting games. I haven't played GG in over a year, but I picked up and beat I-no in 3 continues on normal mode fighting best 2 of 3.

Do not put down your controller. Every fighter I play will eventually cost me a new controller because they are frustrating, but the reward of knowing you are solid steel in a video game is awesome. being indominatable in the arcade is a hell of a feeling, but best of all, making your friends/siblings suffer the same torture you did. That's the ultimate prize. Don't quit!! train! train harder and harder and harder! =) cause once you've had your fill of whooping computers and friends, you will no doubt seek out rivals.

And if you quit, you'll never make a suitable rival >=3 Bwahaha!