Its working now after reinstalling the Nvidia drivers for my GPU of all things

1.1.1.1 Hotfix 2 is working fine for me, Win 10x64, version 1903, build 18362.3 (Insider's beta of the official release sometime in the next week or two), and I played for better than 90 minutes last night without a single crash. Game is running great: AMD R5 1600 @ 3.8GHz, 16 GB (2x8GB) sys ram @ 3200Mhz, RX-590/480 8GB Crossfire, Adrenalins 19.4.1. (I doubt the game is running in Crossfire mode, however--probably running only on the RX-590 running @ 1.6GHz.) Fantastic game--much superior to what I thought I was buying--a kind of D2 clone--this is much, much better!