NoNewTaleToTell: Currently trying to get into Deus Ex GOTY but I'm finding it extremely difficult to feel comfortable with the controls, which is a shame since apparently this is the type of game that I would love. Apparently there is a Ps2 port of it, so I might track that down and give it a try.
The controls will get much better when you invest some skill points into whatever your using. It's quite clunky at the begining, later it will be super smooth actions and your reticule and accuracy will be super fast.
The poison knock out cross bow works great if your a beginner. Running right up and shooting people in the face with a pistol works well, a few points in a knife you can sneak up and stealth kill stuff. Working on a silenced Sniper rifle to keep your distance also works well.