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Without a doubt: Witcher series or Pillars of Eternity.
Post edited October 04, 2015 by menganogog
Risen series
Witcher series
Dragon Age Origins series
Mass Effect series (haven't played 2 and 3 but 2 is really good if you believe gaming mags)
Ultima series (only have played 7and 8)
Neverwinter Nights series
Drakensang series

To name a few good ones I have played
Try some of the Forgotten Realms games that were recently released here.