In game achievements, as opposed to the meaningless "this is to let the developer know you finished the tutorial" kind of achievements. I want to accomplish some non main storyline side adventure and be rewarded for it. Something like "you killed 100 ogres with a butter knife, you now get the knife fighter perk" or even the hidden packages in the GTA games, it'snot something you'd normally do during the normal course of play.
Also, game play paths that are mutually exclusive. Like you can't join the Merchants Guild and the Thieves Guild with the same character. Or taking the dual wielding pistols perk prevents you from taking the pacifist perk. Unfortunately though, most games can't even get conversation choices right. It always irks me when your conversation choices don't actually have an impact on the conversation as all dialouge option lead to the same result. If you tell off an NPC there should be actual consequences, maybe even benefits, instead of "You're right, my face is ugly. For being honest I'll give you the treasure map handed down to me from my grandfather."