PookaMustard: Or you could use
play.it though I haven't tried it because the above just works for me.
Disclaimer: I am the original author and main developer of ./play.it, so everything below this line is obviously biased.
If you already know how to use WINE directly, ./play.it would not bring any big benefit.
The only extras it does for The Witcher 3 is to install DXVK in the dedicated WINE prefix (something you probably already do) and to generate native packages (.deb for Debian, .pkg.tar.zst for Arch Linux, etc.) for a streamlined installation process. Well, and a couple other things but these are minor and not related to the way the game runs (like diverting saved games to ~/.local/share/games/the-witcher-3 or the ability to skip the expansions and only install the base game).
For this specific game it is mostly useful for people who do not already know how to work with WINE, and for people who would like all their games to be installed through their distribution-provided packages manager.