Matruchus: Total Annihalation, Total Annihalation Kingdoms, Celtic Kings: Rage of War, 8-bit Armies, Empire Earth 1+2, Stronghold HD + Crusader, Perimeter + Emperor's Testament, Cossacks Anthology, Knights and Merchants, Earth 2140-2160, Battle Realms, KKND 1+2, American Conquest, AI War, Star Ruler 2, Heroes of Annihilalated Empires, Sins of a Solar Empire, Impossible Creatures, Dungeons 2, Darkest Hour, Meridian: New World, Stronghold Crusader 2, Warrior Kings and Battles. Act of War. There are more there if you like bigger crossgenre mixing.
If you like Total War games you have: Imperial Glory or Dragon Commander
Newer games that are pure RTS: 8-bit Armies! Ashes of the Singularity
Edit: Star Wars Galactic Battlegrounds as mentioned by Hunch. Essentially Age of Empires in Star Wars setting.
^ what he said, that pretty much covers it. Don't forget World in Conflict which is different and well done in its own right.