squid830: Well ever since 2.0, I haven't even been able to reach the title screen or menu, with either 2.0 or 2.1.
Not using mods, updated drivers, tried many ways of cleaning out old drivers and re-installing - so far nothing works.
I don't have Phantom Liberty (and likely won't ever bother getting it), in case that matters...
QWEEDDYZ: strickt security issue of your system. reinstall game (and Galaxy!) to D/Games/Cyberpunk-2077/ and use admin run mode for first launch (for Galaxy too).
I ALWAYS use a "/games/" folder for all games - in this case "G:/games/" for my external SSD. So "security" shouldn't be an issue, no other game complains (and if it did surely the message would be different).
However, what I DID do was edit the config file (that seems to have been created in my user local AppData despite the fact I deleted it entirely), and I manually set all the graphics options in that config file to lower settings, ensuring that DLSS started OFF.
This also didn't work, so then I reinstalled the entire thing from scratch using Galaxy.
For good measure, I also removed and then reinstalled the C++ Runtime 2015-2019, both the 64-bit version and the 32-bit version.
Then I ran the game and it bloody worked!
I'm actually not sure which of those things finally did it - but if I had to guess maybe the C++ runtime? Before that I THOUGHT I had reinstalled it, but it was likely a different C++ Runtime and not that specific one... Either that or the painstaking editing of the config file, but that seems far less likely.