When I try to run X-Com: Enforcer, it goes fullscreen, gets just a couple of frames into the first into video and then it always freezes and crashes to desktop. This happens regardless of which video device I have set, this happens if I try running the game in its safe mode. I've tried all I could think of. I tried running the game executable as administrator or in different compatibility modes. I tried using dgVoodoo instead of nGlide for the game. I thought maybe it's a video codex issue, so I downloaded and installed RAD Tools which from what I understand includes the Bink video codec. That also did not help.

I am completely at a loss. Does anyone have any ideas what might help? I'm on Windows 10 with GeForce GTX 1650 graphics card, if that might have anything to do with anything.

Just a few hours after posting that, I managed to find the answer myself in a lone Steam forum post. Turning off Data Execution Protection on Windows 10 lets the game run properly. There is an exception list in the settings, but for whatever reason that is not sufficient, I have to just disable DEP completely.

Hello...

Unfortunately I was late to the party, hehe. XD
Well, I'm glad you solved the problem and thanks for sharing it with us! =)

Getting straight to the point... Have you tried this(?):
Delete these files from the root directory...

3DfxSpl.dll;
3DfxSpl2.dll;
3DfxSpl3.dll;

glide.dll;
glide2x.dll;
glide3x.dll;

nglide_config.exe.

Download and install the latest version of "nGlide": https://www.zeus-software.com/downloads/nglide

The GOG installer uses an obsolete version of nGlide and perhaps that was your problem... By installing the latest version of nGlide the game will receive some enhancements that may improve overall performance. Keep in mind that GOG's offline installer is dated 2016-02-17, and the latest version of nGlide to date is from 2019 (if memory serves).

Note: If you are going to try my possible solution, don't forget to change the nGlide settings through the "nGlide Configurator". Completely disabling DEP is not recommended, as it will leave your PC system vulnerable to external attacks.

Anyway, here's my tip for you and others who stumble upon this topic. ;)

Cheers! \o