Trying to figure out how to get this working. Its the same problem in Diablo.

I will open the game then a few seconds in ( 10s or so ) the screen would flicker, I would be unable to select any of the options until I alt tabbed, the game would crash a few seconds later.

Anyone else having this issue?

Display is 3440x1440 144hz
fullscreen
aspect correction on
scaling screen fit
vsync app set

enhancements 16AF 8AA

Same here. I bought it yesterday and it worked fine, but today it crashes

Same here, tried it out today for the first time and it fails to start sucessfully.

Well do not alt-tab :|
nvidia terrible on backward compatibility even for DX10/Vista+ games. Not the case Wrapper version but onlybfor non enhanced.
Look to general troubleshooting guide, windows article, Nvidia and nvidia Inspector (3rd party tool) articles on PCGW. And Blizzard games dedicated articles there too.

For Wrapper its more like pseudo-security of Windows. Although flickering is not one of the symptoms.

PCGW wiki has GOG articles linked (and opposite). Where closing overlay apps described as mandatory to solve specific visual issue. But actually any isses. Nahimic, MSI, RivaTuner, Discord, input devices apps NOT part of drivers, Nvidia Experience (it is NOT a part of driver!).
Uninstall MSI, RivaTuner RTSS and NV Experience. Install RivaTuner if you think you need it but only from original non-MSI source. MSI have no relations to this app.