Just got this today. The game starts fine does the publisher intros but then crashes to the desktop.

Windows 10 64 bit

AMD Ryzen 5600G
AMD RX 6500 XT
32 gig ram

Only Gog game in my library that has ever done this too

See this thread. Maybe the solutions there can be of some help to you.

https://www.gog.com/forum/venetica/does_not_start_up_at_all

Thank you.... I ended up fixing it on my own by just updating Nvidia Physyx to the latest version.