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I'm having a problem with the game crashing every fifteen minutes--it looks like to the second, practically.

System Specs:
Windows 10 Pro 64
i7 2600k
8 GB RAM
NVIDIA GTX 580

I've tried compatibility settings, as well as the troubleshooting wizard in Win10, all to no avail.

Any help is greatly appreciated.
Try launching it with Vanhelsing_x64.exe instead of vanhelsing.exe ;-)
Iiiinteresting...like maybe it's eating up RAM, hitting 2GB or whatever and crashing? Amazing that we actually need 64-bit CPUs (finally) :-D