In Theory yes, but you are going to have a hard time. Good guns are not found early, enemies resistance to gunpower can be found early. Ideal combo is a mix of melee and range, but if you use a Toreador and employee Auspex too, or a Malkavian, you can somehow pull it off. Keep in mind most supernaturals are naturally resistance to bashing and that most guns, deal primarily bashing damage...