As you might have known, the Nuvie-port of Ultima 6 was recently integrated into ScummVM, adding features such as a much needed drag and drop inventory, enhanced UI, and many more fixes, basically turning the game into Ultima VII.

It's biggest problem is that it runs a game created for 320x200 monitors in your native resoultion, which zooms the game out considerably. That level of zoom strains the eyes, makes you see far more than you should, and is overall neither the intended nor an acceptable way to play such a great game.

There are a couple of threads on the topic all over the internet, but none provides a good, concise solution. They usually offer only ideas what might work.

Since I have managed to solve the problem with information collected from here and there, I thought, maybe I should compile my findings and give a simple step by step instruction for posterity.

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1. Integrate the enhanced game in ScummVM and pick the following graphic settings (tick override global settings):

Use a scaler of your choice (I recommend either Normal for the original style or TV for subtle scanlines)
Use 2x scaling
Tick the box "Filter graphics"

2. Start the game once to save your ingame settings in the scummvm.ini

3. Find your scummvm.ini > USERNAME\AppData\Roaming\ScummVM

4. Find [ultima6_enh] and add the following lines

video/screen_width=426
video/screen_height=240
video/game_width=426
video/game_height=240

...or the equivalent for your aspect ratio when not using a 16:9 monitor

5. Start the game via ScummVM

6. Enjoy

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Screenshots of my game using TV scaling:
https://i.imgur.com/0yD5xK5.png
https://i.imgur.com/gEEhCaL.png

FYI, I believe all of the Nuvie features are included, and you should be able to enable any of them using that terminology. So, for example, if you want to enable the fullscreen interface, you would use

input/interface=fullscreen

The full set of Nuvie features can be found here:
http://nuvie.sourceforge.net/?page=docs

I personally prefer:
input/interface=fullscreen
input/doubleclick_opens_containers=yes
input/new_command_bar=yes
video/game_style=original+_fullmap

Just wanted to add this:

If you want to use the FM Towns sound fx, the config no longer accepts an absolute path, but will load them just fine if you have the FM Towns files under your Ultima 6 directory, eg.:

[ultima6_enh]
sfx=towns
townsdir=u6fmt
speech_mute=true

Above works if the FM Towns Ultima 6 files are under D:\games\ultima6\u6fmt, but if

townsdir=D:\games\ultima6\u6fmt

it fails to load.

Might be specific to Windows, but that's how I got it working.