etb: Trine works fine with Wine.
Just install in a clean wineprefix both the game and the nvidia physx.
Just after use winetricks to install wmp10. If you still have problems install d3dx9_36 too.
I'm just about ready to try an buy this. I installed the demo and it seems happy as can be. I didn't install wmp10, can I ask why you made mention of this? The demo installer had an option for installing a windows video codec, which I allowed, but I really didn't have to do anything. I am hoping its the same way for the full version.
****Edit****
Now running the game via wine 1.3.28 Using 64-bit linux mint 12
The installer wanted to update Direct X. I did not allow this action.
For notion I had first installed the demo for the game. I did allow the video codec to be installed. I did not allow it to update DX
Play so far seems very authentic. I would expect it to be on par with playing it natively.
***Edit***
Updated to wine 1.4 without issue
Have now played through the entire game without any noticeable issues of any kind. A perfect wine experience.