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How do I do it without losing a single process? I can get him quite far; down to 800HP or so, but then I just get swarmed at some point a lose a process. I read some people using "Help" to great effect, but I don't seem to be able to use "Help" at all, in a fight with the SPINE.

I also serously regret picking "Cull" and "Get". "Get" is only somewhat usefull as a passive, while for the rest it is just a worse version of "Breach",.. unless you actually use "Cull". "Cull's" characteristic of launching targets in the air, even as an upgrade, has a huge backfire, in that cells are blasted away from Red.
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I beat the Spine allready, after I gave "Help" another try,.. you really have to spawn him more or less before you start the fight. Once it starts, you won't have a chance. And "Load", buffed up "Load" (+"Breach"+"Cull") does sooo much damage. Bit odd though; I feel like this really was the only way to do it, which is quite unlike this game so far. Usually there are more roads to Rome with this game.