etb: Honestly, it depends a lot on what you want to do. But here are some suggestions:
A wizard-like character: Storm + Spirit.
The classic warrior: Warfare + Defense. Warfare Dual Wield may seems strange with Defense as you cannot use the shield, but there still plenty of useful skill: Battle Awareness, Armor Handling, Adrenaline, Rally, Colossus Form... and the skill points are not so many anyway.
The pet-friend: Spirit + Nature. 2 Wolves, 1 Driad, 1 Lich-King, and seldom an Outsider. If you manage to find a +2 to all Skill item, you can have 3 Wolves. Nature + Dream also works.
The magic knight: Warfare + Dream. Warfare focuses on one enemy, Dream focuses on groups. 100% awesome.
The vicious killer: Warfare + Rogue. Warfare Dual Wield is lethal. You will improve it even more with Mandrake and Blade Honing.
Have fun!
Runesmith: Runes + Defense. This is the ultimate shield using warrior. You gain a bonus shield recovery bonus in runes ontop of the various bonuses from defense. You also gain a left mouse button attack from runes.
Seidr Worker: Runes + Dream. I don't know how to describe this other than OP.