Avernian: I don't know about the reviewers but in my experience, messing up the design so badly that you had to restart from scratch was extremely rare. I went through 95% of the scenarios with the initial design that I started with.
Granted, you may have to resize or remove a room or two along the way because you researched a new technology and need the space or just thought of a more efficient layout, but having to scrap everything was very rare.
I think the game handles that pretty nicely in fact. It starts you out slow with relatively few rooms and little traffic and lets you monitor the effectiveness of this simple system (which gradually becomes more complex) and see how it manages the discovery of new illnesses, emergencies, epidemics and the steadily growing number of patients that start giving your hospital a shot as your fame and popularity grows.
You will of course continue to learn new tricks along the way, especially from mistakes in your design that lead to congestion, long waiting times and ultimately the death of the unfortunate Elvis-imitator whose King-complex was left untreated for so long that he just couldn't take it anymore.
But these mistakes can usually be rectified on the go by resizing, shuffling rooms around or simply buying new realestate lots to place extra rooms of the type that seems to generate the greatest demand (which you can hopefully do before the death toll gets too high).
The only real issues I had with having to adjust my initial designs were usually at the very beginning when you find out that the gate you thought to be the entrance to your hospital was actually the backdoor - on some maps it's not always obvious where the patients will be coming from and you don't find that out until they start coming, at which point you already had to lay out an initial design of sorts. That's when you do a silent facepalm and start over, but fortunately that doesn't happen too often and it's never too much work to redo. Which is a good thing too as I also hate having to scrap my hard work, just like you.
When you start a new scenario, you will of course have to build a new hospital from the ground up and that repetition does lead to a bit of a burnout after a while, but this is still a game I keep coming back to even 15 years after first getting my hands on it in the late 90s. It's a charming little gem that I have no second thoughts about recommending to anyone interested in economic managerial games. :)
PS: Elvis Lives
Wow, you've been so helpful, and I appreciate it! I think I'm gonna go ahead and take a chance on Theme Hospital. It sounds like it's got good replay value, which is what I'm looking for as I have too many unfinished games, and a few I don't care to play again. I'm hoping it'll go on sale again soon. My gaming addiction's getting too expensive. :-)