When you change your mouse settings in Windows (10) for "left handed" use - change primary and secondary buttons; the in-game menu (or game-menu) doesn't seem to respond to that. I don't know if this is a Known Issue and whether it is already being considered or worked on, or if there's is another work around for this problem. I may not have a problem as I can use other Key Bindings to do the same thing, but the Quick Access Menu behaves in the same way and therefore it becomes quite difficult to actually use that in the way it was meant to be used.

Let me know if this helps or if you have any suggestions otherwise.

EDIT: I do have to add that I think this is a general problem, especially for left handed players. I realize that when using the Map for instance you have the same problem; I would therefore say that this is a critical issue for left handed players that are using a mouse and keyboard and hope that it is taken into consideration by the developers.