I just got to chapter 3 yesterday and play for like 30 minutes into it.
Then I turn on my PC today, and fires up the game without modifying the game or my pc in any way, and I then proceed to enter a house and the game crashes to desktop with no errors or anything.
I tried again and the same thing happened, but this time windows told my screen driver stopped responding. So I updated the video card driver. And now the game won't even start at all, just starts up a black screen and crashes with no error.

My system is well above the recommended requirements and I play fully maxed out.
i7 920 @ 2,66 ghz
GTX 295 (tried disabling multi GPU mode)
6 gigs of ddr3 ram
Windows 7

I already tried running the game in windowed mode, reinstalling and run as admin/compability mode.
Btw, it's the retail platinum edition enhanced edition, not the GOG one, but I felt this forum would be best.