Ostarion: I am having a similar problem and have tried several methods as suggested by the gog.com articles on resolving the issues (including but not limited to: compatibility, graphic drivers, screen resolution, firewall bypassing, administrative and full control options enabled) However, it seems that the core of the problem is in the screen size based on the error messages I receive in the file that records these errors.

06:58:58: Error: problem with SDL_SetVideoMode (400, 300): No matching GL pixel format available
06:58:58: Error: Unable to open screen surface.
06:58:58: Error: Init failed, could not load game

The first error changes depending on what resolution I have the setting at, but I have tried all resolution setting for the sake of elimination and there are no changes to the other two error messages.

I admit to not being a computer expert but everything I have is up to date, I even tried older drivers to see if perhaps updates didn't take certain situations into account

Ostarion: Yes it is, I forgot to check before, but once you told me, I went to a website to check my drivers (which are as up to date as possible) and it supports up to and including OpenGL 3.1. I also meet all other requirements in the requirements list. I have considered going back to an even older driver than before, but I don't think that's the best approach. I do know that others are experiencing similar issues with very different computers from mine, though still Windows 7, would that perhaps be part of it, I have already tried the administrative, compatability option.

Of course, all of the other Daedelic games work perfectly on my PC (I am a fan of them after all) and most of the more recent ones have the same requirements. That's why I am confused why this one doesn't work.