I was thinking about getting this game as a Christmas present for my nephew who is currently using a computer installed with Edubuntu. Does anyone know if this game will run in Linux with Wine or DosBox?

Not with Dosbox as it's a Windows game. I did get Myst ME running well in Wine about 6 months back, but had to to a bit of fiddling with older QuickTime versions to get it working. I'm sure this version can work, but maybe not out of the box.

Awesome, thanks. It's a little late for Christmas, but a backup birthday present is always nice.

For those interested, this does run quite well under Crossover 11. Just use the unsupported title profile, and install. Aftwerwards setup a managed window, as I have had issues with closing the game, then finally install QT7 into that bottle and you are good to go.