bukowski: I don't know how technically inclined you are, but if you're comfortable with installing WIne on either platform (Linux or Mac), then Technobabylon will run flawlessly.
I'm currently playing it on a mid-2015 rMBP running OS X 10.11.3 (El Capitan).
I've been trying to get this to work on my mac osx 10.7 (Lion) installation as well. I've got the wineskin working properly, and it installs technobabylon successfully using the GOG installer. But when I try to play in full screen, there's this crazy mouse acceleration that makes the game unplayable. The cursor moves too unpredictably. It works just fine in windowed mode, but I prefer to play in full screen. Were you able to get your installation to work with full screen and no mouse acceleration? if so, how? And do you have the same problem when running in 640x480?
I believe GOG uses some sort of custom wineskin because I can run all the Blackwell series games just fine in fullscreen, but it seems as though they're also just using wineskin for their GOG Mac editions of their games as well. So there must be a way around this mouse problem.
EDIT: I haven't found a good wineskin engine to use for this game. They flicker in full-screen mode unless I use engine 1.7.1noflicker. Oh well. The other wadjet eye games work fine even on very old wineskin engines. I can load up Technobabylon fine using crossover mac. So there is an easy way to use wineskin to play the game, but I'm not sure which skin corssover is using.