I installed the game yesterday and played two sessions. All in all about 6 hours without any issues.
One day later, and I can't start it. The game will show the following error:

LowLevelFatalError [File:Unknown] [Line: 729]
BulkData compressed header read error. This package may be corrupt!

I used GOG game integrity check. No issues.
I reinstalled the game.

Nothing helps.

@kominikx: A very big thank you from me. That solved the problem.
You rock :)

Appreciate the help but why would you not tell anyone where tf the save files are at?

[url=https://www.pcgamingwiki.com/wiki/System_Shock_(2023)#Save_game_data_location]https://www.pcgamingwiki.com/wiki/System_Shock_(2023)#Save_game_data_location[/url]

I can play for about 3 minutes before:

---------------------------
The UE4-SystemShock Game has crashed and will close
---------------------------
LowLevelFatalError [File:Unknown] [Line: 198]
Unreal Engine is exiting due to D3D device being lost. (Error: 0x887A0006 - 'HUNG')

---------------------------
OK
---------------------------

EDIT: I deleted %USERPROFILE%\Saved Games\Nightdive Studios\SystemShock\Saved\SaveGames\ and it apparently fixed the issue. Which makes NO SENSE as this was my first game -- there were no previous save games...

EDIT2: I played the game for several hours, no issues. Rebooted the system today, opened the game -- same freeze in minutes. How will I be able to play a saved game if I must delete it first?

EDIT3: Crashed again. I had to delete the Nightdive Studios folder again and GoG I'm guessing, restored the save game files and I was able to play without a crash. Such a strange bug, Nightdive...