Everytime i try to cross the bridge just outside the hotel the game crashes. Ive tried to change all gfx settings but it wont help. The characters graphics also flickers sometimes.

Im running the game on windows vista 32bit as an administrator with UAC disabeled.

Have you tried different compatibility modes and disabling visual themes and desktop composition? You can do so by right clicking the games shortcut and choosing properties. Then all the options are on the compatibility tab.

If that doesn't help could you please post your system specs?

Crash on crossing the bridge and model flickering sounds like a drivers related issue

Check this thread.