The game crew has established (several times) that whether you use the locker system or not is inconsequential for the difficulty encountered; and that they have not "balanced" anything taking that system into account (you can play the game as if it didn't exist, they are not forcing you to use it). If something happens to you in a head-start game, it can happen as easily while starting from surface level.
Xentios: Tips for who want to win with engineers.
-Do not waste time from starting floor 1. It is imposible for engineer to start from floor 1 and win the game.
It isn't.
Xentios: -Forget psi and psionic powers. Even if you invest 100 brain and 100 Power your psi powers still suck as hell. Just use them for scout purpose and invest other skills even if they need +2.
Many of the powers have specific use, learning when and why to get them and use them is part of the experience. Manipulation, TK fist and Psi Shield are especially useful for otherwise non-psi inclined characters.
Xentios: -Always fight if there is someting to fight for in that room.
Or close the door and forget about it if it's too costly to obtain, of course.
Xentios: -You need a mecha-controller. Without it you can never clean a mecha room and gain more ammo then you waste. Recharge it when you need. Do not use a energy weapon as long as you dont have to. Use energy cells to replenish mecha-controler.
Sorry for my ignorance, but what is a mecha-controller?
Xentios: -Do not be greedy use things when you need to use but dont over do it.
After a few runs it's quite easy to know which items are more common and which are not, deciding what to use first when having several choices for the same objective is only a matter of common sense. In any case, if you got'em, use'em... it's a permadeath game, no point in saving anything if the situation is desperate.