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What are the best Graphis Options?
VGA 356
MCGA 256
EGA 16 color
Tandy 1000 16 Color
CGA 4 color

What is the best sound Option?
IBM Generic sounds
Tandy Sounds
AdLib sound board
Roland MT-32 MIDI board
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-Best gfx: VGA
-Best sound: Adlib

Adlib is digital sound; it was either concurrent with or immediately preceded Soundblaster, can't remember.

-Actual best sound: Roland MT-32

Roland is analog and sounds incredible. Microprose made it an option for all of their games. But to use it, you either need the actual hardware (an MT-32 board) or an emulator you have set up already for dosbox.