ferguson: Never encountered any game breakers in Call of Pripyat in either vanilla or this mod...
There are a few game breakers in CoP, and some carry over to mods like Complete and Misery (a missing body, going into an open bunker that should be locked, getting stuck in a certain spot were a trigger fails to move things along).
They're very random and loading a game that's old enough can give you another shot at missing the bug. Complete seemed pretty good at avoiding the bugs and ran into 2 game breakers a few times in Misery excluding the 1 I knew how to avoid (all also in the original) though I did play through Misery many times extensively so game time wise I'd guess those bugs didn't actually happen more often.
For me, having put countless hours into CoP (original/Complete/Misery) Complete was the most stable for me and I'm the kind that runs back and forth doing as much as I can, selling all I can, wrapping up everything first if I feel there's a point of no return etc, in other words playing and exploring extensively as opposed to just following the next quest.
Unfortunately the Stalker games are rather finicky in that one person could have loads of problems and another have pretty smooth sailing. A few PCs ago I had endless trouble with the Stalker games on the other hand the last two PCs have been almost perfect (other than the actual in game bugs), only problem on the current PC is frame rate drops around certain fires but that can be solved with limiting the Flip Queue size (equivalent of Nvidia cards pre-render frame limit).