TreuloseTomate: I bought SpaceChem a couple of weeks ago on GOG and it has been working just fine until yesterday. Since then, when I try to start the game, I get the black window for a second and then it crashes without a message. I haven't done any changes to the game or to my system as far as I know. This is on 32-Bit Vista.
I've tried editing the config.ini like disableFBOs, fullscreen mode, etc... Nothing works. Then I've made a backup of my save folder and uninstalled and reinstalled the game. Then the game starts properly, and I can create a new profile and play the game. But when I quit and try to start again, it crashes... Turns out the .locals file in the SpaceChem save folder is somehow responsible. When I delete it, the game starts fine. But when there is a .locals file located in the SpaceChem folder, no matter if it's a new one created by the game or my own backup save, it crashes.
Please help! I'm near the end of the game (Pseudoethyne) and want t finish it. :O

e: nvm
Found this on reddit.
http://www.reddit.com/r/spacechem/comments/1wx42g/spacechem_crashes_on_launch/

korell: What?! According to the reddit article you've linked to, the SpaceChem crashes are because the game couldn't connect to the game's website? That sounds like DRM, and as such should not be happening to the GOG version as it should be DRM free here.

TreuloseTomate: As far as I know, the game tries to download statistics from the server during launch. The server isn't just offline. You seem to get redirected to somewhere else, and this is causing the game to crash. When I'm not connected to the internet, the game won't crash.