I think the maximum resolution supported by the game is 2048x1536, even with the modified D3D renderer.

You could try 1920x1200 or 2048x1280 if your monitor supports that resolution.
You might be better off running at a 16:9 aspect resolution (1920x1080 or at most 2048x1152) though, as the horizontal field of view has been modified to suit that ratio - 16:10 and narrower will result in some "squishing" / distortion of the image.

EDIT: another possible cause of this crash is if you're trying to run the modified D3D renderer with the original exe rather than the d3d_SlaveZero.exe

Seems like choosing some of the recommended resolutions makes the game work, but the FPS are a bit lower so maybe I'm having too high of a resolution still?

But the bigger issue for me is that the game's displayed in a window or something, surrounded by the typical Windows 8 window frames and it's pretty distracting when I prefer to play in full screen. But we're on the right track here, at least.

Maybe - the game seems to have some performance issues in certain areas (eg. the sewer levels).

I'm not sure if there's a significant performance difference between the (modified) D3D renderer and nGlide.

Hmm, windowed mode isn't enabled in your szOptions.ini - might be a compatibility issue with Windows 8 and the D3D renderer.

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Using nGlide bypasses many of the compatibility issues and limitations of Slave Zero's D3D renderer.
You might not be able to use bump-mapping or true color textures, but overall it's more reliable (on modern PCs), avoids the offset crosshair / broken lock-on bug, and allows you to do crazy stuff like running Slave Zero at 3840x2160 :D (pillarboxed to 4:3) [3.2MB image]

....or you could go a step beyond crazy and run it at 7680x4320 (which I think might be the highest resolution supported by nGlide) using GeDoSaTo

Changing the resolution to 640 x 480 really helps out the offset. I can lock on the enemy. But I can't change the nGlide settings to higher resolution. Changing it also change the in-game resolution too and in the game it can't be altered.

===EDIT===

Oh I finally understand. I must change the resolution in the configuration file manually and it don't alter the nGlide settings. Thanks for the help in your older post. XD