I am on Win7, 6950 2GB, i7 2600k, 8 RAM

I changed the compatibility mode to WinXP and Win98, ran it as administrator, and fiddled with all of the settings on nglide.

I get nothing. Sin.exe has stopped working.

I need help with this.

Try changing from nglide to Opengl.

How do I do that?

There should be a shortcut in start menu - GOG.com - SiN Gold - Graphic mode setup

I can't load up the menu, sin.exe crashes immediately.

I ended up solving my problem by launching Wages of Sin (which doesn't crash for whatever reason) and selecting the Original Sin campaign.

Thanks though.

This worked for me. Load up Wages of Sin (press the windows key and use start to search for it.) and launch the original campaign through the campaign selector.