LotBlind: Did you mess around with it?
Not really. I only did some quick "testing" to see whether there's a difference at all.
The only thing I'm sure about is that their damage is increased.
It's hard to recommend it for speedrunning, as most parts will force you to slow down. Hitscan enemies like the Reconah will destroy you unless you take the time to make use of cover.
Even regular Grunts can kick your ass in small groups, or otherwise make sure that you need to hunt down some health and/or armor afterwards.
But if you end up giving it a try regardless, I'd love to see your attempts :-)
And something offtopic:
In case you didn't know about the following cvars, they might make the game slightly more comfortable to play/run.
If want to try them out, simply copy-paste them into "autoexec.cfg" (create in main directory).
set bob_roll 0
set bob_pitch 0
set bob_up 0
set run_pitch 0
set zoomscale 0.3
set s_mixahead 0.05
set sensitivity 2.3 The first four eliminate all forms of swaying (simulating your head going up/down/left/right as you move).
s_mixahead controls how many seconds the audio is delayed. If you hear glitches (pops, crackles), just increase it (to 0.1 for example). Default is 0.2.
zoomscale controls how much your sensitivity is reduced when you zoom in with the sniper rifle. Not a very important command I suppose. Default is 0.1111.
I assume you know about
sensitivity, but I just added it in case you didn't. The game only allows big jumps in (mouse) sensitivity if you use the in-game slider, but if you use this cvar, you can fine-tune it way more precisely.
There's also
run_roll, but it doesn't seem to have any effect.
Maybe you don't care about this at all, but I figured they might be nice if you'll be speedrunning this :-)