Has anyone else had any luck getting this to run in fullscreen?

I can only get it to run in windowed mode. I'm running OSX 10.9.1 on a mid 2012 Macbook pro.

I've got the same problem as you, and the same computer as well

I am also having the same issue, tried messing with the wine settings to force full screen and still had no luck. It will be full screen during the logo splash, but then when the menu loads up its windowed again. Really frustrating.

You've probably tried this already but go into the video controls within the game menu and try 1024x768. For me, that's the highest resolution I can use and keep Sin at full-screen. If I choose any higher, the game goes back into windowed mode. This, of course, is using the default OpenGL renderer.