Classic old game - there are probably other ways to get this -game- going in linux, but for the record this GOG title installed faultlessly and seemingly runs just dandy using cxgames on linux - I'd be hopeful the same would be true for the Mac version of crossover. (I'd be sortta hoping the same holds true for other GOG productions using cxgames/linux...I'll be happy to test if you like ;-)
Later today I'll add this app to the codeweaver's compatibility database with an appropriate ranking. I'll then likely give it a good hammering (and the brain obviously) to check it runs as it should and everything works 'as expected'...then bump the rating.
Well done GOG crew - it's good to have this back on my desktop, great job.

If you are using a non-Windows platform, it would be easier to simply use a native ScummVM build for your platform.

"I'd be hopeful the same would be true for the Mac version of crossover."
Simon the Sorcerer works fine with the Mac version CrossOver Games.
edit: As does Simon the Sorcerer II.

You can try CrossOver 7 Pro Full http://tips-linux.net/en/content/crossover

Definitely. I'm doing this right now, and the game runs flawlessly.