Hello,

is it possible to run the game solo with "No-PK Mod"?

Why on Earth do you want to ruin your own fun?

Yes, you can solo the whole game, even with PK, let alone NoPK.

Dealing with PK is fairly standard, either two snapshot lazer at *close* range (one each hand) or one shot and move around the corner where it cant get at you. Or PWM1 at barely safe range. Or a full DP barrage at the back of the head, aim at head, and rely on your own fairly high shoot to trust sufficient bullet get through. DP ammo= SVT. the only kind that penetrate.
+++ NOTE: I dont know if it's anything Diehard or Difficulty Grade Changes mods do, but you can use frags to damage pilots. The idea is using the fragment pieces in frag grenades to cause critical damage to get past defense. You will need, say 10+ F1, and some handy corner. Get in near at the position that you cant shoot at it, but you can throw grenades. Get in a few hit then move back into safe position. If chase, move elsewhere. 10-15 F1 later and hundred of fragment flying around will cause damage.

The key is lots of obstacle at *close* range so that if you can quickly hide behind some thick cover.

At late game, I am always thankful that we have PK to unleash our overpower arsenal and skills.

But playing solo is... 90% boring and 10% sheer terror. Not my kind of fun.