After getting in to setup once I have been unable to open it I have tryed all compality modes on vista and still no luck plus it will not open on XP at all. Anyone else having this problem?
Only error I get is can not run in full screen mode.

don't you have to use dosbox to open the setup file ?

I tryed that and same thing it opens to a point then closes. I tryed a new dosbox and still no luck plus I reinstalled it to a new location.

I have also had problems with setup but the method below seems to work for me. Might be worth a try-
Go into your GOG screamer directory and open (and backup) the dosboxScreamer file, find the line starth.exe and replace with setup.exe. Next find the line cycles=max and replace with cycles=20000. Now click the screamer shortcut that GOG makes for you and setup should start.
This might make setup a bit slow but I am sure you can increase the cycle amount and still keep it stable in order to change your settings.
Once you have done just revert the settings in the dosboxScreamer file (or replace it with the backup file). Hope this works for you.

I'll try it once I get home todayt and let you know. Thanks

That work Latsan the setup is now opening again now I can work on getting the joypad working right. Like to steer hard left.