Sorry to dig this up after so long, but I just finished the game and it made more sense to reply here then start a new thread.
The system requirements currently say, "ATI/AMD - Sanitarium requires graphic card drivers version 13.4 or older". This is a driver version so ancient that it doesn't support my card. I decided to throw caution to the wind and buy the game anyway. It was a bit glitchy, but largely playable.
Windows 10 64-bit
AMD drivers 22.2.1
Installed and launched via GOG Galaxy
No tweaks or mods of any kind
I think there was a performance option in the settings menu that I cranked up to max quality
• Choosing a dialog option would severely slow down animations in the background, until the speech ended and you returned to the dialog choices. Sometimes grating, but a lot of the time I was focused on the conversation.
• The cursor had a dark vertical stripe blinking in and out, on the right side. A minor annoyance.
• Lastly, the worst bug was during the puzzle with the chalkboards. Moving the mouse would corrupt the display, as seen in the screenshot. Thankfully, right-clicking would exit the chalkboard closeup but keep the letters you found. So it was tedious but at least not game-breaking.
That's it. I experienced no crashes or anything else. Sanitarium is currently listed as
untested in ScummVM, so maybe that's something to look into if you're having trouble.