Honestly Sacred 2 is broken for me, i never managed to run this game flawless.

64bit Windows 10 = crash every 1 to 2 hr (Memory Leak)
- Settings everything on Low
- some ini tweaks

32bit Windows 10 = same as 64 bit

Windows XP = still the same Problem

I tried many settings, CM patch, Programs (Mem Cleaner etc.) just nothing, the only thing is what you can do is hit often F7 and hope for the best.
It is a shame, such an good game :(

System:
Intel I7-3770K
16GB RAM
GTX 980

Latest Community Patch worked for me fine (almost no crashes). But you must take a risk and make an exception in your AV software to minimize risk of interruption.