After my initial test run, i noticed that both the inventory doesn't work anymore (Controller is properly detected, but the button to call up the inventory always pulls up the options menu, no matter where it is mapped to) and that auo-aim ceased to work.
Both things worked fine the first time i started the game and haven't worked since.
And without inventory, the game is pretty much unplayable.

Fresh install, only settings changed were Anti-Aliasing and Filtering, no mods installed.
I'm using a basic XBONE controller, but as said, the games options menu detects it and lets me config it without issue.

EDIT:
Add to that: The character select screen keeps shuffling ID's as if a direction is being held.
Issues persist through reinstallation.