So RE2 works perfectly except the voices are SO loud. All other sounds, running shooting is perfect, but as soon as someone opens their mouth they nearly blow my eardrums out.It starts on the opening FMV.

Is there anything I can do? I cant keep taking me headset completely off everytime someone talks..

The sound quality on the base PC versions are all terrible. You would need to use the HQ Audio mods. I don't believe any have been updated to work with base GOG, but the ones in the big thread below should work for the most part.

You are looking for the lexas87 HQ audio mods in the Rebirth conversion thread below.