Ralackk: If you go to your start menu folder of this game there should be a setup shortcut open that(as administrator on windows7/vista by right clicking it.). You can then try out different sound settings from there and test them in the setup to see which ones work on your computer.
Seems to have done the trick. Don't know, I think maybe something was conflicting with the audio earlier because it was on Awe 32 or whatever before and it didn't work and now it does so, who knows. Just wish there was a separate volume for the music but, game seems okay. Little hard actually. Been killed some 10 times on the first level already. Quit a difference from say Doom