Quern is enjoyable but it still uses many of the same tropes in the adventure genre: follow recipes, make potions, operate exotic-looking gadgets, sliding blocks, etc. We've seen these in many other games already.
The most ground-breaking adventure game in recent years is The Return of Obra Dinn, which offers refreshing puzzles and refreshing ways to solve them, not to mention a refreshing visual style. The whole game is like nothing you've ever seen.
Obduction is also refreshing in that you have to "swap" areas to achieve the various goals, which is a unique and memorable gameplay mechanic.
The Witness has Myst-like environment too, but the puzzles try to be very different. A game in which you do nothing but draw lines on grids doesn't sound like much. But kudos to the game designers, they pulled it off. Who knew drawing lines on a grid could have such variety?
Quern is in a more traditional mold. Another traditional adventure game I enjoyed recently is The Eyes of Ara, currently on Steam only. I have nothing against traditional designs. But for the genre to move forward, innovations need to keep coming -- especially when the adventure genre has been left for dead over the years.