While I did manage to 100% the game, it'd be a much less frustrating experience if I didn't have to quit the game every few minutes (on average – sometimes it happened after a dozen seconds or so) due to all 3D objects suddenly gaining visual artifacts – also random in nature (ranging from demonic/pitch black eyes & windows to acid trip color scheme). The change occurred most often after a level load, but sometimes it happened during the cinematic, and at least once during the (final) boss fight.

…I was running the Linux version, on an AMD GPU.

Yeah, I think it's an issue with AMD.

Played through the game on nVidia and had zero issues.