I've installed the latest versions of all the community efforts mentioned in the mods guide. I'm running Windows 7, 64-bit.

My game is crashing quite frequently in the Hive. It seems to happen only when leaving interior areas, regardless of how often I've saved or what else I've done, etc. I just keep reloading until it works.

Only now, I can't progress at all. I walked through the first portal found in Ragpicker's Square, where there's a single piece of junk. I walk back towards the now nonexistent portal, and the game soon crashes. I haven't played PST before, so I can't confirm, but I think a sequence is being triggered here.

Any suggestions? I haven't changed my resolution once or anything of that sort.

I too am having this exact same issue.
I'm running Windows 7 x64, game's in Administrator mode, I have the mods from the mod guide installed (have tried a separate install without them too, problem persists).

I did a bit of testing and found:
It occurs more frequently if you use the quicksave (Q) function in an area, regardless of how long ago you quicksaved or anything else you did in that area after quicksaving. Loading of quicksaves also appears to trigger the issue.
The crashes only appear to happen in the Hive, Ragpickers and the Warehouse are notorious spots where it happens on almost every exit whereas it seems to be possible to leave the Flophouse almost every time without issue (had one crash out of about a dozen transitions).
The crashes don't occur when entering a smaller map (e.g. going into the Flophouse/Warehouse/Ragpickers) but only when exiting them to re-enter the Hive hub areas.

I've managed to complete maybe two quests in the Hive as my patience for this sort of thing is extremely short and I'm one of those scummy gamers who loves the quicksave button like it dispenses coke and cookies when pressed.

Has anyone at all found a solution to this issue that allows quicksaves to continue functioning?

My game has also crashed three times in the past hour. Running the same specs as original poster.

I started a game and play for several hours last night with no issues. Now I have crash problems when I enter a building from the Hive.

Any help or ideas?

UPDATE

after reading the post above, i deleted my Quick Save folder and then loaded the auto-save file. I played for another hour with no problems. Seems like a Quick Save issue.