I'm playing my 2nd game on Veteran, and thought I'd do ok w/ my normal band of 20th level PCs, but I kept getting wiped. So I did some internet searches to find various strategies and builds/gear etc. that have worked. And yes, there is 1 of 2 unique drops that make the fight worth winning, beyond bragging rights--a mythical upgrade (I had assumed legendary was the top level until now).
Watcher: Fighter, but acted more like a tank for much of the fight.
Eder: Swashbuckler, using the Animancer's Energy Blade (Raw dmg so doesn't worry about Penetration); Blackened Plate Armor w/ the upgrade that lowers an enemy's Armor Rating by 1.
Xoti: you'll obviously need her healing etc. She wore a Bone Setter's Torc (3 charges of removing all Injuries etc.)
Konstantin: I didn't do this, but re-speccing him if need be to get the 8th tier ability "With all your Strength, Slay the Beast" (+20 Accuracy, +30% dmg) would have been a good idea! But I kept him firing away w/ the hunting bow that does extra dmg b/c he's a dwarf, and summoning creatures (drakes and weapons mainly).
Maia: the arquebus Red Hand (shorter range but 2 shots at a time).
There are other items that give +Accuracy > Beasts of course. Important are the best healing potions, and Luminous Adra potions (remove injuries) for the 2 melee types near her. Once she gets down to 75% health, you have to start worrying about Consume attacks that give 1-2 Injuries. There's a animation windup that tips you off and you're supposed to run away (taking a Disengagement attack is much preferable), but I was so busy focusing on other things, I never could avoid those attacks. But between a few L. Adra potions and that Bone Setter's Torc, I survived.
The thing to keep in mind is that Belranga is almost invincible early on, as you'll see when you try to hit or damage her. Her defenses are ridiculously high. The trick is to start lowering her defenses by killing spider minions, but the danger is that her offense gets better when that happens. The sweet spot is probably between 60-70 minions and then try to take her down quickly. KEY: the soulblade dagger's ability that automatically kills (1/rest) anything (!) w/ less than 25% health. That little dagger's been Eder's mainstay weapon for much of the game, and I switched to it as soon as I could.
Her normal AR is 15, but only 8 v Crush/Corrode. I didn't use any crushing or corrosive attacks; just an example of another way to whittle her down (once her defenses are in the normal realm). Different things will work, just be patient. I held off on summoning from items for a good while. Also, items or food that prevent being paralyzed (Dex affliction) are crucial for at least the 2 melee types (Shark's soup for Eder).
This is just what worked for me; other companions and builds can work too if you do a little searching. Quite the challenge! Now I'll go get spanked on the newer megaboss (the ooze) and try to figure out who and what I need to beat it...